Armstrong RA, Winsper SJ, Blair JA (1995) Hypothesis: is Alzheimer's disease a metal_induced immune disorder? Neurodegeneration 4:107_111
Bennett SA, Stevenson B, Staines WA, Roberts DC (1995) Periodic acid_Schiff (PAS)_positive deposits in brain following kainic acid_induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood_brain barrier breakdown. Acta Neuropathol Berl 89:126_138
Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross_linking in Alzheimer disease. Acta Neuropathol Berl 89:291_295
Das S, Potter H (1995) Expression of the Alzheimer amyloid_promoting factor antichymotrypsin is induced in human astrocytes by IL_1. Neuron 14:447_456
De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropathol Exp Neurol 54:175_187
Furuta A, Price DL, Pardo CA, Troncoso JC, Xu ZS, Taniguchi N, Martin LJ (1995) Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. Am J Pathol 146:357_367
Griffin WS, Sheng JG, Roberts GW, Mrak RE (1995) Interleukin_1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol 54:276_281
Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM (1995) Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol Berl 89:35_41
Meda L, Cassatella MA, Szendrei GI, Otvos LJ, Baron P, Villalba M, Ferrari D, Rossi F (1995) Activation of microglial cells by beta_amyloid protein and interferon_gamma. Nature 374:647_650
Monning U, Sandbrink R, Weidemann A, Banati RB, Masters CL, Beyreuther K (1995) Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells. J Biol Chem 270:7104_7110
Morgan TE, Laping NJ, Rozovsky I, Oda T, Hogan TH, Finch CE, Pasinetti GM (1995) Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. J Neuroimmunol 58:101_110
Mrak RE, Sheng JG, Griffin WS (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol 26:816_823
Perlmutter LS, Barron E, Myers M, Saperia D, Chui HC (1995) Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer's disease lesions. J Comp Neurol 352:92_105
Uchihara T, Kondo H, Akiyama H, Ikeda K (1995) Single_laser three_color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque_related structures in post_mortem human brain tissue. J Histochem Cytochem 43:103_106
Walker DG, Yasuhara O, Patston PA, McGeer EG, McGeer PL (1995) Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease. Brain Res 675:75_82
Wisniewski HM, Wegiel J (1995) The neuropathology of Alzheimer's disease. Neuroimaging Clin N Am 5:45_57
Yamada T, Yamanaka I (1995) Microglial localization of alpha_interferon receptor in human brain tissues. Neurosci Lett 189:73_76
Yamada T, Miyazaki K, Koshikawa N, Takahashi M, Akatsu H, Yamamoto T (1995) Selective localization of gelatinase A, an enzyme degrading beta_amyloid protein, in white matter microglia and in Schwann cells. Acta Neuropathol Berl 89:199_203
Aisen PS, Davis KL (1994) Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 151:1105_1113
Akiyama H (1994) [Alzheimer's disease and the immune system response]. Nippon Rinsho 52:2990_2994
Akiyama H, Nishimura T, Kondo H, Ikeda K, Hayashi Y, McGeer PL (1994) Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis. Brain Res 639:171_174
Akiyama H (1994) Inflammatory response in Alzheimer's disease. Tohoku J Exp Med 174:295_303
Akiyama H, Ikeda K, Katoh M, McGeer EG, McGeer PL (1994) Expression of MRP14, 27E10, interferon_alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue. J Neuroimmunol 50:195_201
Atanassov CL, Muller CD, Sarhan S, Knodgen B, Rebel G, Seiler N (1994) Effect of ammonia on endocytosis, cytokine production and lysosomal enzyme activity of a microglial cell line. Res Immunol 145:277_288
Bernstein HG, Wiederanders B (1994) An immunohistochemical study of cathepsin E in Alzheimer_type dementia brains. Brain Res 667:287_290
Cacabelos R, Alvarez XA, Fernandez Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin_1 beta in Alzheimer's disease and vascular dementia. Methods Find Exp Clin Pharmacol 16:141_151
Connor JR, Boeshore KL, Benkovic SA, Menzies SL (1994) Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res 37:461_465
Cotton P (1994) Constellation of risks and processes seen in search for Alzheimer's clues. JAMA 271:89_91
Dahlstrom A, McRae A, Polinsky R, Nee L, Sadasivan B, Ling EA (1994) Alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia. Investigations with cell cultures and human cortical biopsies. Mol Neurobiol 9:41_54
Eikelenboom P, Zhan SS, Kamphorst W, van der Valk P, Rozemuller JM (1994) Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. Virchows Arch 424:421_427
el Hachimi KH, Foncin JF (1994) Do microglial cells phagocyte the beta/A4_amyloid senile plaque core of Alzheimer disease? C R Acad Sci III 317:445_451
el Hachimi KH, Foncin JF (1994) Do microglial cells phagocyte the beta/A4_amyloid senile plaque core of Alzheimer disease? C R Acad Sci III 317:445_451
Frederickson RD, Brunden KK (1994) New opportunities in AD research__roles of immunoinflammatory responses and glia. Alzheimer Dis Assoc Disord 8:159_165
Griffin WS, Sheng JG, Gentleman SM, Graham DI, Mrak RE, Roberts GW (1994) Microglial interleukin_1 alpha expression in human head injury: correlations with neuronal and neuritic beta_amyloid precursor protein expression. Neurosci Lett 176:133_136
Hartig W, Hausen D, Brauer K, Arendt T, Bigl V, Bruckner G (1994) Digoxigenin_tagged anti_GFAP and multiple labelling of human glia, vessels and beta_amyloid. Neuroreport 5:573_576
Kimura H, Tooyama I, McGeer PL (1994) Acidic FGF expression in the surroundings of senile plaques. Tohoku J Exp Med 174:279_293
Kuiper MA, Visser JJ, Bergmans PL, Scheltens P, Wolters EC (1994) Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci 121:46_49
Lee SC, Liu W, Brosnan CF, Dickson DW (1994) GM_CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12:309_318
Liberski PP (1994) Transmissible cerebral amyloidoses as a model for Alzheimer's disease. An ultrastructural perspective. Mol Neurobiol 8:67_77
Liew SC, Penfold PL, Provis JM, Madigan MC, Billson FA (1994) Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae. J Neuropathol Exp Neurol 53:150_157
Maat Schieman ML, Rozemuller AJ, van Duinen SG, Haan J, Eikelenboom P, Roos RA (1994) Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. J Neuropathol Exp Neurol 53:483_491
Matsuse T, Namba Y, Ikeda K, Inoue S, Hosoi T, Ouchi Y, Fukuchi Y, Orimo H (1994) Immunohistochemical and in situ hybridisation detection of adenovirus early region 1A (E1A) gene in the microglia of human brain tissue. J Clin Pathol 47:275_277
Matsushima GK, Taniike M, Glimcher LH, Grusby MJ, Frelinger JA, Suzuki K, Ting JP (1994) Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell 78:645_656
McGeer PL, Klegeris A, Walker DG, Yasuhara O, McGeer EG (1994) Pathological proteins in senile plaques. Tohoku J Exp Med 174:269_277
McGeer PL, Walker DG, Akiyama H, Yasuhara O, McGeer EG (1994) Involvement of microglia in Alzheimer's disease. Neuropathol Appl Neurobiol 20:191_192
McGeer PL, Rogers J, McGeer EG (1994) Neuroimmune mechanisms in Alzheimer disease pathogenesis. Alzheimer Dis Assoc Disord 8:149_158
McRae A, Rudolphi KA, Schubert P (1994) Propentosylline depresses amyloid and Alzheimer's CSF microglial antigens after ischaemia. Neuroreport 5:1193_1196
Morris CM, Kerwin JM, Edwardson JA (1994) Non_haem iron histochemistry of the normal and Alzheimer's disease hippocampus. Neurodegeneration 3:267_275
Muller CD, Bocchini V, Giaimis J, Guerrieri P, Lombard Y, Poindron P (1994) Functional beta_glucan receptor expression by a microglial cell line. Res Immunol 145:267_275
Munch G, Taneli Y, Schraven E, Schindler U, Schinzel R, Palm D, Riederer P (1994) The cognition_enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. J Neural Transm Park Dis Dement Sect 8:193_208
Nieto Sampedro M, Mora F (1994) Active microglia, sick astroglia and Alzheimer type dementias. Neuroreport 5:375_380
Pasinetti GM, Johnson SA, Oda T, Rozovsky I, Finch CE (1994) Clusterin (SGP_2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. J Comp Neurol 339:387_400
Pei JJ, Sersen E, Iqbal K, Grundke Iqbal I (1994) Expression of protein phosphatases (PP_1, PP_2A, PP_2B and PTP_1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Res 655:70_76
Perlmutter LS, Myers MA, Barron E (1994) Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microsc Res Tech 28:204_215
Perlmutter LS (1994) Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 9:33_40
Petanceska S, Burke S, Watson SJ, Devi L (1994) Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: an in situ hybridization study. Neuroscience 59:729_738
Renkawek K, Voorter CE, Bosman GJ, van Workum FP, de Jong WW (1994) Expression of alpha B_crystallin in Alzheimer's disease. Acta Neuropathol Berl 87:155_160
Saura J, Luque JM, Cesura AM, Da Prada M, Chan Palay V, Huber G, Loffler J, Richards JG (1994) Increased monoamine oxidase B activity in plaque_associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience 62:15_30
Schumacher U, Adam E, Kretzschmar H, Pfuller U (1994) Binding patterns of mistletoe lectins I, II and III to microglia and Alzheimer plaque glycoproteins in human brains. Acta Histochem 96:399_403
Schumacher U, Kretzschmar H, Pfuller U (1994) Staining of cerebral amyloid plaque glycoproteins in patients with Alzheimer's disease with the microglia_specific lectin from mistletoe. Acta Neuropathol Berl 87:422_424
Singhrao SK, Neal JW, Piddlesden SJ, Newman GR (1994) New immunocytochemical evidence for a neuronal/oligodendroglial origin for corpora amylacea. Neuropathol Appl Neurobiol 20:66_73
Stanley LC, Mrak RE, Woody RC, Perrot LJ, Zhang S, Marshak DR, Nelson SJ, Griffin WS (1994) Glial cytokines as neuropathogenic factors in HIV infection: pathogenic similarities to Alzheimer's disease. J Neuropathol Exp Neurol 53:231_238
Vasilakos JP, Carroll RT, Emmerling MR, Doyle PD, Davis RE, Kim KS, Shivers BD (1994) Interleukin_1 beta dissociates beta_amyloid precursor protein and beta_amyloid peptide secretion. FEBS Lett 354:289_292
Verbeek MM, Otte Holler I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RM (1994) Accumulation of intercellular adhesion molecule_1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol 144:104_116
Yamada T, Horisberger MA, Kawaguchi N, Moroo I, Toyoda T (1994) Immunohistochemistry using antibodies to alpha_interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues. Neurosci Lett 181:61_64
Yamada T, Tsubouchi H, Daikuhara Y, Prat M, Comoglio PM, McGeer PL, McGeer EG (1994) Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c_MET) in human brain tissues. Brain Res 637:308_312
Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T (1994) Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues. Brain Res 658:163_167
Youdim MB, Lavie L (1994) Selective MAO_A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life Sci 55:2077_2082
Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL (1993) Expression of intercellular adhesion molecule (ICAM)_1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol Berl 85:628_634
Akiyama H, Ikeda K, Kondo H, Kato M, McGeer PL (1993) Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease. Neurosci Lett 164:233_235
Banati RB, Kreutzberg GW (1993) Flow cytometry: measurement of proteolytic and cytotoxic activity of microglia. Clin Neuropathol 12:285_288
Beyreuther K, Pollwein P, Multhaup G, Monning U, Konig G, Dyrks T, Schubert W, Masters CL (1993) Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome. Ann N Y Acad Sci 695:91_102
Cacabelos R, Alvarez XA, Franco Maside A, Fernandez Novoa L, Caamano J (1993) Effect of CDP_choline on cognition and immune function in Alzheimer's disease and multi_infarct dementia. Ann N Y Acad Sci 695:321_323
Carpenter AF, Carpenter PW, Markesbery WR (1993) Morphometric analysis of microglia in Alzheimer's disease. J Neuropathol Exp Neurol 52:601_608
Coria F, Moreno A, Rubio I, Garcia MA, Morato E, Mayor FJ (1993) The cellular pathology associated with Alzheimer beta_amyloid deposits in non_demented aged individuals. Neuropathol Appl Neurobiol 19:261_268
de la Torre JC, Mussivand T (1993) Can disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 15:146_153
Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75_83
Gordon MN (1993) Microglia and immune activation in Alzheimer's disease. J Fla Med Assoc 80:267_270
Ironside JW, McCardle L, Hayward PA, Bell JE (1993) Ubiquitin immunocytochemistry in human spongiform encephalopathies. Neuropathol Appl Neurobiol 19:134_140
Kalaria RN (1993) The immunopathology of Alzheimer's disease and some related disorders. Brain Pathol 3:333_347
McRae A, Dahlstrom A, Polinsky R, Ling EA (1993) Cerebrospinal fluid microglial antibodies: potential diagnostic markers for immune mechanisms in Alzheimer's disease. Behav Brain Res 57:225_234
Peress NS, Fleit HB, Perillo E, Kuljis R, Pezzullo C (1993) Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease. J Neuroimmunol 48:71_79
Sandbrink R, Banati R, Masters CL, Beyreuther K, Konig G (1993) Expression of L_APP mRNA in brain cells. Ann N Y Acad Sci 695:183_189
Scott SA, Johnson SA, Zarow C, Perlmutter LS (1993) Inability to detect beta_amyloid protein precursor mRNA in Alzheimer plaque_associated microglia. Exp Neurol 121:113_118
Tanzi RE, Wenniger JJ, Hyman BT (1993) Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res Mol Brain Res 18:246_252
Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R (1993) alpha 2_Macroglobulin expression in neuritic_type plaques in patients with Alzheimer's disease. Neurobiol Aging 14:233_237
Wisniewski HM, Weigel J (1993) Migration of perivascular cells into the neuropil and their involvement in beta_amyloid plaque formation. Acta Neuropathol Berl 85:586_595
Araujo DM, Cotman CW (1992) Beta_amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res 569:141_145
Barcikowska M, Kujawa M, Wisniewski H (1992) beta_Amyloid deposits within the cerebellum of persons older than 80 years of age. Neuropatol Pol 30:285_293
Connor JR, Menzies SL, St.Martin SM, Mufson EJ (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res 31:75_83
Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW (1992) Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 48:763_777
Evans PH, Yano E, Klinowski J, Peterhans E (1992) Oxidative damage in Alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions. EXS 62:178_189
Frederickson RC (1992) Astroglia in Alzheimer's disease. Neurobiol Aging 13:239_253
Ikeda K, Akiyama H, Haga C, Haga S (1992) Evidence that neurofibrillary tangles undergo glial modification. Acta Neuropathol Berl 85:101_104
Ishii T, Haga S (1992) Complements, microglial cells and amyloid fibril formation. Res Immunol 143:614_616
Jacobs RW, Duong T, Scheibel AB (1992) Immunohistochemical analysis of the basal forebrain in Alzheimer's disease. Mol Chem Neuropathol 17:1_20
Johnson SA, Lampert Etchells M, Pasinetti GM, Rozovsky I, Finch CE (1992) Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol Aging 13:641_648
Ling EA, Dahlstrom A, Polinsky RJ, Nee LE, McRae A (1992) Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience 51:815_825
McGeer PL, Rogers J (1992) Anti_inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42:447_449
McGeer PL, Akiyama H, Kawamata T, Yamada T, Walker DG, Ishii T (1992) Immunohistochemical localization of beta_amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy. J Neurosci Res 31:428_442
Palacios G, Palacios JM, Mengod G, Frey P (1992) Beta_amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Brain Res Mol Brain Res 15:195_206
Perlmutter LS, Scott SA, Barron E, Chui HC (1992) MHC class II_positive microglia in human brain: association with Alzheimer lesions. J Neurosci Res 33:549_558
Rozemuller JM, van der Valk P, Eikelenboom P (1992) Activated microglia and cerebral amyloid deposits in Alzheimer's disease. Res Immunol 143:646_649
Su JH, Cummings BJ, Cotman CW (1992) Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience 51:801_813
Wegiel J, Wisniewski HM (1992) Tubuloreticular structures in microglial cells, pericytes and endothelial cells in Alzheimer's disease. Acta Neuropathol Berl 83:653_658
Wisniewski HM, Wegiel J (1992) The role of perivascular and microglial cells in fibrillogenesis of beta_amyloid and PrP protein in Alzheimer's disease and scrapie. Res Immunol 143:642_645
Wisniewski HM, Wegiel J, Wang KC, Lach B (1992) Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol Berl 84:117_127
Yamada T, McGeer PL, McGeer EG (1992) Some immunohistochemical features of argyrophilic grain dementia with normal cortical choline acetyltransferase levels but extensive subcortical pathology and markedly reduced dopamine. J Geriatr Psychiatry Neurol 5:3_13
Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ (1992) Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol 141:249_259
Akiyama H, Kawamata T, Dedhar S, McGeer PL (1991) Immunohistochemical localization of vitronectin, its receptor and beta_3 integrin in Alzheimer brain tissue. J Neuroimmunol 32:19_28
Blass JP, Ko L, Wisniewski HM (1991) Pathology of Alzheimer's disease. Psychiatr Clin North Am 14:397_420
Cacabelos R, Barquero M, Garcia P, Alvarez XA, Varela de Seijas E (1991) Cerebrospinal fluid interleukin_1 beta (IL_1 beta) in Alzheimer's disease and neurological disorders. Methods Find Exp Clin Pharmacol 13:455_458
Cras P, Kawai M, Siedlak S, Perry G (1991) Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease. Brain Res 558:312_314
Eikelenboom P, Rozemuller JM, Kraal G, Stam FC, McBride PA, Bruce ME, Fraser H (1991) Cerebral amyloid plaques in Alzheimer's disease but not in scrapie_affected mice are closely associated with a local inflammatory process. Virchows Arch B Cell Pathol 60:329_336
Esiri MM, Morris CS (1991) Immunocytochemical study of macrophages and microglial cells and extracellular matrix components in human CNS disease. 2. Non_neoplastic diseases. J Neurol Sci 101:59_72
Fillit H, Ding WH, Buee L, Kalman J, Altstiel L, Lawlor B, Wolf Klein G (1991) Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett 129:318_320
Frohman EM, Frohman TC, Gupta S, de Fougerolles A, van den Noort S (1991) Expression of intercellular adhesion molecule 1 (ICAM_1) in Alzheimer's disease. J Neurol Sci 106:105_111
Masliah E, Mallory M, Hansen L, Alford M, Albright T, Terry R, Shapiro P, Sundsmo M, Saitoh T (1991) Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease. Acta Neuropathol Berl 83:12_20
McGeer PL, McGeer EG, Kawamata T, Yamada T, Akiyama H (1991) Reactions of the immune system in chronic degenerative neurological diseases. Can J Neurol Sci 18:376_379
McRae A, Ling EA, Polinsky R, Gottfries CG, Dahlstrom A (1991) Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system. Neuroscience 41:739_752
Miyazono M, Iwaki T, Kitamoto T, Kaneko Y, Doh ura K, Tateishi J (1991) A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation. Am J Pathol 139:589_598
Ohgami T, Kitamoto T, Shin RW, Kaneko Y, Ogomori K, Tateishi J (1991) Increased senile plaques without microglia in Alzheimer's disease. Acta Neuropathol Berl 81:242_247
Perlmutter LS, Barron E, Saperia D, Chui HC (1991) Association between vascular basement membrane components and the lesions of Alzheimer's disease. J Neurosci Res 30:673_681
Vandenabeele P, Fiers W (1991) Is amyloidogenesis during Alzheimer's disease due to an IL_1_/IL_6_mediated 'acute phase response' in the brain? Immunol Today 12:217_219
Wood JG, Zinsmeister P (1991) Tyrosine phosphorylation systems in Alzheimer's disease pathology. Neurosci Lett 121:12_16
Akiyama H, Tago H, Itagaki S, McGeer PL (1990) Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease. Acta Neuropathol Berl 79:537_544
Akiyama H, McGeer PL (1990) Brain microglia constitutively express beta_2 integrins. J Neuroimmunol 30:81_93
Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA (1990) Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Res 513:181_192
Cras P, Kawai M, Siedlak S, Mulvihill P, Gambetti P, Lowery D, Gonzalez DeWhitt P, Greenberg B, Perry G (1990) Neuronal and microglial involvement in beta_amyloid protein deposition in Alzheimer's disease. Am J Pathol 137:241_246
Cras P, Gheuens J, Lubke U, Boons J, Vandermeeren M, Van Heuverswijn H, Martin JJ (1990) A monoclonal antibody raised against Alzheimer cortex that specifically recognizes a subpopulation of microglial cells. J Histochem Cytochem 38:1201_1207
Grundke Iqbal I, Fleming J, Tung YC, Lassmann H, Iqbal K, Joshi JG (1990) Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol Berl 81:105_110
Jellinger K, Paulus W, Grundke Iqbal I, Riederer P, Youdim MB (1990) Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J Neural Transm Park Dis Dement Sect 2:327_340
Mandybur TI (1990) The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis. Acta Neuropathol Berl 80:307_310
Mattiace LA, Davies P, Yen SH, Dickson DW (1990) Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol Berl 80:493_498
Mattiace LA, Davies P, Dickson DW (1990) Detection of HLA_DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 136:1101_1114
Ohyagi Y, Takahashi K, Kamegai M, Tabira T (1990) Developmental and differential expression of beta amyloid protein precursor mRNAs in mouse brain. Biochem Biophys Res Commun 167:54_60
Perlmutter LS, Barron E, Chui HC (1990) Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 119:32_36
Styren SD, Civin WH, Rogers J (1990) Molecular, cellular, and pathologic characterization of HLA_DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol 110:93_104
Wegiel J, Wisniewski HM (1990) The complex of microglial cells and amyloid star in three_dimensional reconstruction. Acta Neuropathol Berl 81:116_124
Wisniewski HM, Vorbrodt AW, Wegiel J, Morys J, Lossinsky AS (1990) Ultrastructure of the cells forming amyloid fibers in Alzheimer disease and scrapie. Am J Med Genet Suppl 7:287_297
Bancher C, Grundke Iqbal I, Iqbal K, Kim KS, Wisniewski HM (1989) A 31 kilodalton beta_protein immunoreactive polypeptide in neuronal lipofuscin. Prog Clin Biol Res 317:913_924
DeFeudis FV (1989) Novel therapy for Alzheimer's disease. Neurobiol Aging 10:467_468
Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C (1989) Brain interleukin 1 and S_100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86:7611_7615
Haga S, Akai K, Ishii T (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol Berl 77:569_575
Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24:173_182
Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 135:309_319
McGeer PL, Akiyama H, Itagaki S, McGeer EG (1989) Immune system response in Alzheimer's disease. Can J Neurol Sci 16:516_527
Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL (1989) A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 48:674_691
Rozemuller JM, Eikelenboom P, Pals ST, Stam FC (1989) Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA_1 family. Neurosci Lett 101:288_292
Wisniewski HM, Wegiel J, Wang KC, Kujawa M, Lach B (1989) Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can J Neurol Sci 16:535_542
Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH (1988) Alzheimer's disease. A double_labeling immunohistochemical study of senile plaques. Am J Pathol 132:86_101
Hauw JJ, Duyckaerts C, Delaere P, Chaunu MP (1988) [Alzheimer's disease, amyloidosis, microglia and astrocytes]. Rev Neurol Paris 144:155_157
Itagaki S, McGeer PL, Akiyama H (1988) Presence of T_cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue. Neurosci Lett 91:259_264
Luber Narod J, Rogers J (1988) Immune system associated antigens expressed by cells of the human central nervous system. Neurosci Lett 94:17_22
McGeer PL, Itagaki S, Tago H, McGeer EG (1988) Occurrence of HLA_DR reactive microglia in Alzheimer's disease. Ann N Y Acad Sci 540:319_323
McGeer PL, Itagaki S, McGeer EG (1988) Expression of the histocompatibility glycoprotein HLA_DR in neurological disease. Acta Neuropathol Berl 76:550_557
McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA_DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285_1291
Rogers J, Luber Narod J, Styren SD, Civin WH (1988) Expression of immune system_associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9:339_349
Schmechel DE, Goldgaber D, Burkhart DS, Gilbert JR, Gajdusek DC, Roses AD (1988) Cellular localization of messenger RNA encoding amyloid_beta_protein in normal tissue and in Alzheimer disease. Alzheimer Dis Assoc Disord 2:96_111
McGeer PL, Itagaki S, Tago H, McGeer EG (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA_DR. Neurosci Lett 79:195_200
Rozemuller JM, Eikelenboom P, Stam FC (1986) Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study. Virchows Arch B Cell Pathol 51:247_254
Vostrikov VM (1985) [Electron_cytochemical study of microglia in Alzheimer's disease and senile dementia]. Zh Nevropatol Psikhiatr 85:974_976
Glenner GG (1979) Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med Hypotheses 5:1231_1236
Samorajski T (1976) How the human brain responds to aging. J Am Geriatr Soc 24:4_11